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GLP-1 is a hormone naturally produced in the intestine in response to food intake

This is significantly higher than the 2.4% to 3.1% average reduction seen with diet and exercise alone

As GLP-1 supply grows and insurance coverage expands, prices should drop

The appetite feedback coefficient for tirzepatide (k=48) is marginally lower than semaglutide (k=49), which means the appetite rebound component may be very slightly less aggressive, potentially contributing to a somewhat longer active loss phase in some individuals

Weight loss in non diabetic patients is not as well documented at the 14 mg maximum dose

Evidence-based effective and safe interventions in ASD are needed to ease some of the behavioral challenges seen in this condition