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Dose Escalation GLP-1 medications are typically introduced at a low dose and increased gradually

Specifically, GLP-1RAs exert protective effects on exercise-induced cardiomyopathy via increasing autophagy, reducing inflammation-related proteins and ROS generation via restoring the expression of catalase and manganese superoxide dismutase (MnSOD) [81]

This aligns with when you want the compound present and active

The American Journal of Cardiology 248:6772

Phase 3 trials are ongoing and will provide more definitive efficacy and safety data

pSivida Announces Phase I/II Clinical Study Evaluating Bioerodible Sustained Release Latanoprost Device in Ocular Hypertension and Glaucoma