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Safety concerns included uncharacterized immunogenicity risks, inadequate impurity and endotoxin testing in available raw material, the unresolved free-base versus acetate salt form distinction, and, for BPC-157 specifically, an angiogenesis mechanism that raises theoretical concerns for patients with undiagnosed tumors

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229,230,231,232,233 SIRT5-mediated desuccinylation also participates in protection against peroxisome-induced oxidative stress via targeting ACOX1

Food Bioscience, 28, pp.183-191