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As we get older, our natural production of glutathione declines and our stores become depleted
Hence, some researchers have recommended lower doses given over extended cycles of 8-12 weeks
Additionally, nutritional deficiencies that sometimes accompany rapid weight lossparticularly iron deficiencycan result in low hemoglobin levels (below 12.5 g/dL for women and 13.0 g/dL for men), another common reason for temporary deferral
189,190 Meanwhile, long-term high-protein intake may increase urinary calcium excretion but may also raise IGF-I and protect the skeleton from weight loss-induced bone loss
The most common reason relates to the medication's gastrointestinal side effects, particularly nausea, vomiting, and diarrhea
Ongoing research will look at how GLP-1s may control cancer progression
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