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In the model proposed by Lee, homocysteine is shunted away from the methionine synthesis pathway and toward the GSH synthesis pathway, creating a relative deficiency of methyl donors in order to keep up with increased demand for the glutathione needed for POP conjugation ( Fig 3 )

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Studies have shown mixed results regarding fluid intake changes

Price A et al

GPX3 mRNA is present in renal proximal tubular epithelial cells, and GPX3 may have specific antioxidant functions in the renal tubules or extracellular spaces due to the higher concentration of GSH in the kidneys