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The physiological response to exogenous testosterone is further modulated by individual genetic variability, particularly polymorphisms of the androgen receptor gene, which contribute to substantial interindividual differences in efficacy and adverse effect profiles ( The principal mechanisms of action of testosterone include: stimulation of protein synthesis and anabolic pathways, direct activation of androgen receptors in target tissues, psychological effects, such as alterations in mood, motivation, and libido

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Serious side effects are rare but will be closely monitored

With a weight loss of 15%, there is a remarkable reduction in CKD progression, heart failure outcomes, MASLD, cardiovascular events, cancers, cancer mortality, and overall mortality [4, 5]

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