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Because GLP-1 receptor agonists (typically employed as injectables) increase mealtime insulin secretion and reduce postprandial serum glucose, they may work complementarily with basal insulin treatment to achieve blood sugar goals, especially if basal insulin has not been effective in improving after-meal sugar spikes

Abstract 446-P, 2008

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The numbers above and below the proglucagon sequence refer to specific amino acid residues within proglucagon