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FDA and the EMA are evaluating new indications for GLP-1 therapies that highlight their cardiovascular benefits

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This review evaluates the current evidence on combination therapies involving SGLT2is, GLP-1RAs, and nsMRAs in type 1 and type 2 diabetes, thereby focusing on treatments that in type 2 diabetes have shown cardio-renal protection, while exploring future research directions

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A Bayesian NMA of 29,506 adults found retatrutide had the highest efficacy for weight loss but also the highest adverse event risk among all comparators