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A growing body of scientific evidence on mammalian systems indicates that AITC treatment arrests the cell cycle, causes apoptosis and inhibits the proliferation of cancer cells leading to reduced tumour formation in certain types of cancer 14,15

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To overcome these problems, various halogenated derivatives (e.g., chlorinated or boronated PBN), alkylated derivatives having a lipophilic tail (e.g., those with dodecyl chains), bifunctional derivatives (e.g., GS-PBN, Mito-DEPMPO, 5-ChEPMPO, DECPO, and 4-HMDEPMPO), conjugates with drugs or targeting molecules (such as PEG or heparin, that both can cross the BBB), dimers, and cyclodextrin polymers have been developed in the last few years (Han et al., 2009

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doi: 10.1159/000334762 60 CapoC