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Retinoids accelerate cell turnover clearing hyperpigmented cells faster and stimulate collagen synthesis through different pathway than peptides creating additive improvement, though eye area requires gentle approaches using retinaldehyde or low-concentration retinol (0.25-0.5%) rather than stronger prescription tretinoin risking significant irritation in this sensitive region
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For example, participants in a study involving semaglutide experienced an average weight loss of 14.9% of their body weight over a 68-week period
On the question of fertility more broadly: weight loss can improve fertility, particularly in women with PCOS or obesity-related hormone disruption
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NTS, nucleus tractus solitarius
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