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For weight management, NICE recommends liraglutide 3mg (Saxenda) or semaglutide 2.4mg (Wegovy) for adults with a BMI of at least 35 kg/m (or 30 kg/m with weight-related comorbidities) alongside a reduced-calorie diet and increased physical activity

These chemicals have no pedigree, but supplement and peptide vendors sell them, sometimes labeled for "research use only," and they are being acquired by both licensed and unlicensed compounders

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By pairing semaglutide with Regenerons anti-myostatin, trevogrumab, patients could lose similar amounts of body weight, but the weight lost would be 76-80% fat vs

Call NHS 111 for urgent advice if your GP or clinical trial team is unavailable and you are concerned about symptoms that are not immediately life-threatening