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Given tirzepatide's demonstrated efficacywith weight loss exceeding that achieved with other approved medications there is no evidence of additional benefit from adding lipotropic injections , and this combination is not endorsed by clinical guidelines

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The first two reports, both 4 week studies in drug nave patients with relatively mild T2DM, showed that DPP-4 inhibition was well-tolerated in humans and was associated with significantly lower fasting and meal-related glucose concentrations (32, 33)

Excluding the trial judged at high risk of bias for efficacy outcomes likewise did not materially change the estimate (SMD 1.32, 95% CI 2.33 to 0.31

Instead, it typically starts about 2 to 3 months later