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Because there is no 180-day exclusivity for the first biosimilar (only a separate, limited exclusivity for the first interchangeable biosimilar, and only against other interchangeables), the first-mover advantage that drives Paragraph IV filings in small molecules does not exist for biosimilars

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Human ACE2 expression is high in tubular epithelia (from kidney), and the viral hijack of this enzyme could alter sodium transport, affect blood volume/pressure and lead to AKI 308