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This raises the possibility that if a patient ingests some iron supplement tablets during a suicide attempt with an overdose of APAP [83, 84], the mechanism of cell death is switched to ferroptosis, and the accelerated and enhanced severe toxicity can be rapidly fatal [85]

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Thus, the findings suggested that ARA-290 might specifically block the reaction of neurons to capsaicin without affecting other types of heat sensors

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Free Radic Biol Med 180(20):112 Murphy TH, Miyamoto M, Sastre A, Schnaar RL, Coyle JT (1989) Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress