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For many tendon, ligament, muscle, and joint problems, load management and structured rehabilitation are central parts of recovery
[1] [4] Published phase 2 trial data (Jastreboff et al., NEJM , 2023) reported dose ranges from 1 mg up to 12 mg weekly, with higher doses associated with greater weight loss but also increased rates of gastrointestinal side effects
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Individuals with insulin resistance, elevated inflammation, or dysregulated adipose tissue may have blunted beta-3 receptor signaling that limits the peptides effectiveness
However, mild side effects may include: Pain or swelling at the injection site Mild diarrhea Temporary itching or rash Always consult with a healthcare provider before beginning any new supplement regimen
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