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Hypoxia upregulating acss2 enhances lipid metabolism reprogramming through hmgcs1 mediated pi3k/akt/mtor pathway to promote the progression of pancreatic neuroendocrine neoplasms

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GSH is the primary intracellular antioxidant and one of the key regulatory factors in GPX4 expression 30,31 .Through restoration of SLC7A11 expression, OSR facilitated greater cystine uptake and GSH accumulation, while simultaneously lowering the levels of lipid peroxidation by-products such as MDA and 4-HNE

10.1001/archneur.57.10.1439 Arch

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