Diabetes 56:19511959 Eissele R, Gke R, Willemer S et al (1992) Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man
FUNDING This work was supported by the National Natural Science Foundation of China (82300903), the Key R&D Plan Social Development Project of Jiangsu Province (SBE2023741128), the National Natural Science Foundationof Jiangsu Province (SBK20 23022865), the sixth phase 333 second level talent training project of Jiangsu Province (tackling bottleneck technology) (BRA2022008), the Projects from Social Development of Zhenjiang (SH2023029), the Youth Science and Technology Talent Recruitment Project of Zhenjiang city (ZJTJ2101), the Affiliated Hospital of Jiangsu University Beigu Talent Cultivation Plan Project (BGYCB202206), the Affiliated Hospital of Jiangsu University Doctoral Initiation Fund Project (jdfykc2021005)
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Tirzepatide May Be Right for You If You have a BMI of 30 or higher, or 27 or higher with a weight-related health condition You want an FDA-approved medication with well-established clinical evidence You have type 2 diabetes and want to address both blood sugar and weight You prefer a treatment with extensive real-world safety data You have responded well to GLP-1 medications in the past and want enhanced results Retatrutide May Be Worth Discussing If You have significant weight to lose and want a more aggressive metabolic approach Previous dual-agonist or single-agonist therapies have plateaued You are interested in emerging therapies and are comfortable with newer clinical data You have concerns about fatty liver disease, given retatrutides potential hepatic benefits You want a treatment that addresses both appetite suppression and energy expenditure Important Medical Considerations Neither medication is appropriate for individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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