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This hypothesized VEGF/VEGFR interaction may activate a complex intracellular signaling cascade, which may involve multiple proteins such as phospholipase C, protein kinase C, and the mitogen-activated protein kinases
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More than 50 genes have been linked to ALS, with the most common being C9ORF72, which causes up to 50% of inherited cases and 510% of sporadic ones
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