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Weight Fluctuations: Significant or rapid weight loss can leave excess skin that does not fully retract, especially in individuals who have carried excess weight for many years

Peptide therapeutics some of which are conjugated to a fatty acid are larger and more complex than small molecule drugs, Carrick said

Brand-name semaglutide includes Wegovy, which is approved for weight loss, and Ozempic, which is approved for diabetes and, while not approved for weight loss, is often prescribed off-label for this purpose

More clinical evidence can be found on the role of GLP1R agonists such as exenatide can improve vascular endothelial dysfunction in diabetic patients, as has been found in this clinical trial by Hu et al., results suggested that exenatide improved the endothelial dysfunction reflected by digital reactive hyperemia index in newly diagnosed patients with T2DM, and the effect was not inferior to single metformin [59]

Triple agonists that target GLP-1, GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors are now in clinical testing

So far, doctors just havent had very good options for GLP-1 patients who are looking to maintain their weight loss