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Int J Radiat Biol 93:784792

partly for this reason, some promising treatments are never approved, and many arrive too late for people who urgently need them

Pharmaceutics 13 , 1042 (2021)

Normally, the metabolism decreases pharmacological effect but sometimes metabolism produces toxic metabolites or active metabolites

Although several other medications have been linked to DIC, antibiotics remain the leading cause of this condition [60], along with underlying liver disease: for instance, in patients with a history of ICP, there appears to be a greater predisposition toward a cholestatic liver injury from oral contraceptives or postmenopausal hormone replacement, while rifampicin seems to be associated with an increased risk for hepatotoxicity in patients with primary biliary cholangitis (PBC) [64]

Good dental hygiene can help minimize this risk