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Elegant 13 C-NMR analysis ( in vivo injection of labeled glucose, or in some cases acetate, and determination of labeled metabolites) has shown that the glutamine flux in the cycle, V gln in the 13 C-NMR studies, is slightly greater than the flux, V cyc in the 13 C-NMR studies, of released transmitter glutamate and GABA in the opposite direction (Rothman et al., 2011), and that GABA fluxes account for up to 20% of total flux in V cyc (Patel et al., 2005

The same trial found no serious adverse effects, no liver toxicity, and no kidney problems

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Table 2: Variation of regional brain metabolite levels with diagnosis group, age, and sex as fixed effects in robust linear mixed-effects (LME) models

At first, they get 1,000 mcg injections every week for 4-8 weeks

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