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Another consideration is timing

NHS eligibility criteria under NICE TA875 are more restrictive than the MHRA licence, with specific BMI thresholds and service requirements

Someone who weighed 220 pounds losing 2 pounds weekly early in treatment might lose 0.5 pounds weekly at 180 pounds, even with identical medication dose and food intake

Retatrutide might be better suited for those who require massive weight loss and can control or tolerate the increased risk of stomach and heart side effects

These resources point out that interaction risks differ from person to person

This puts sustained treatment out of reach for many Canadians paying entirely out of pocket