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Microdosing GLP-1 means using a lower-than-standard dose, but long-term effectiveness hasnt been confirmed in large clinical trials
They can review whether your current regimen needs adjusting and help manage any overlapping side effects
Head-to-head clinical data from the SURMOUNT-5 trial shows tirzepatide (Mounjaro) achieves greater weight loss
One important caveat is that the GLP-1 that is released naturally in the body lasts mere minutes before it is broken down, whereas semaglutide and other GLP-1R agonists lasts about a week, and are present in circulation at much higher levels
Redox Biol 2:70214
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