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Semaglutide is a GLP-1 receptor agonist originally developed for type 2 diabetes that has gained widespread use for weight management

LGP2 differs from RIG-I and MDA-5 in that it lacks the tandem CARD domains, which presumably impairs its ability to trigger signaling 57 (Fig

It increases GLP-1 and another hormone called glucose-dependent insulinotropic polypeptide (GIP) This means it works in two ways while semaglutide only mimics GLP-1 hormones, tirzepatide also mimics GIP hormones

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Semaglutide has robust randomized trial evidence and an FDA weight loss indication

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