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NAION is the most common optic neuropathy in adults over 50, caused by hypoperfusion of short posterior ciliary arteries supplying the optic nerve, inducing swelling that creates compartment syndrome compressing neighboring axons, resulting in ganglion cell death
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In the presence of neutralizing antibodies, the binding of GLP-1 to GLP-1R is blocked, resulting in a decrease in the fluorescence signal
The pharmacological rationale for combining these two peptides centers on their complementary receptor targets
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