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Patients received an initial dose of either 1 mg, 2 mg, or 4 mg of retatrutide and subsequent doses of either 1 mg, 4 mg, 8 mg, or 12 mg, or they received a placebo throughout the 48 weeks of the study

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Whether a given study design benefits from synchronising with that pulse, or deliberately offsetting it, depends on the readout being measured, because the timing affects whether the exogenous GH signal amplifies or dampens the endogenous pulse

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Across the three trials, rates of hypoglycemic events were low with oral semaglutide 14 mg, empagliflozin 25 mg, sitagliptin 100 mg and liraglutide 1.8 mg

The registration for Ozempic was finalized on August 28th, 2019