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Am J Clin Nutr 1989;49(2):283-289
The standard dosage range of 50-150 mg daily for oral administration aligns with calculated human equivalent doses from animal research
That range is not a mistake
These include acute pancreatitis, acute kidney injury, severe gastrointestinal bowel obstruction, and potential medullary thyroid tumors
The increase in central neural activity is believed to be a consequence of an alteration in the normal balance between excitation and inhibition in nerve transmission, potentially due to a diminution of GABAergic inhibition 50,51,52
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