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Additionally, the time required to complete the enzymatic activity measurements was prolonged, and the method needed to be more easily adaptable to microplate readers due to the necessity of protein precipitation

Pediatrics 2006

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The maintenance in the active state of pyruvate dehydrogenase complex that oxidizes pyruvate to acetyl CoA stimulates oxidative phosphorylation

462 Compared with placebo, long-term administration (e.g., 25 mg or 100 mg every 8 h for 12 weeks) significantly decreased mPAP and improved the 6 min walk distance, with good tolerability

JCI Insight 3 , e122011 (2018)