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10.1016/s0022-3476(75)80983-8 J Pediatr

APP23/PS45 double transgenic mice at the age of 6 weeks were treated with exendin-4 for 8 weeks, while age-matched control APP23/PS45 mice received vehicle solution

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This increases the risk of side effects and could potentially lead to adverse reactions

Studies typically employ subtype-selective antagonists and receptor-expression controls to deconvolute specific receptor contributions to measured biochemical endpoints across cell-based assays and in-vivo systems