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Finally, while genetically predicted higher levels of the medium-chain ACs C8 and C10 were associated with increased depression risk in previous Mendelian randomization analyses, no significant association with depression presence or severity was found for levels of these ACs in the present study

(PubMed) Ma ZF, Skeaff SA

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Semaglutide on the other hand displays limited efficacy in crossing the BBB, but despite this fact it was proven to access the brainstem, septal nucleus and hypothalamus [42]

Poor-quality peptides may contain contaminants, incorrect concentrations, or degraded product that could increase side effect risks or reduce efficacy

J Leukoc Biol 66:411415