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Study methods have used Mercury vapor (Hg 0 ) with oral selenium for 4 weeks in rats [Citation126] oral MeHg + with diphenyl diselenide injection in mice [Citation117], oral mercury (MeHg + and Hg +2 ) with oral selenite for 14 days in mice [Citation128], oral MeHg + with oral selenate for 100 days in rats [Citation126], oral MeHg + with oral selenite for 16 months in rats [Citation130], oral MeHg + with injection of diphenyl diselenide in mice for 21 days [Citation129], and oral MeHg + with oral selenite for 19 weeks in rats [Citation100]

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Given the compounds increasing availability, popularity, and its regulatory controversies, we sought to assess the breadth and quality of preclinical and clinical data supporting its use in musculoskeletal medicine

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