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Why is a blend a poor choice for mechanistic work
Galluzzi L, Bravo-San Pedro JM, Kroemer G
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Lipid peroxidation preferentially accumulates at lysosomal membranes and precedes lysosome rupture, transcription factor EB (TFEB) activation, and cathepsin-dependent plasma membrane breakdown, thereby positioning lysosomal stress at the center of population-scale death amplification
This difference may primarily be due to the auto-activation and subsequent degradation of hHPN WT (Vu et al
