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It is the predominant intracellular non-protein thiol in mammalian tissues, present at concentrations typically ranging from 110 mM in the cytosol, with particularly high concentrations in the liver (up to 10 mM), which is the primary site of GSH synthesis and export

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3.4.3 Inflammation and metabolic contexts Beyond cancer, curcumin increased m 6 A on TRAF4 mRNA by inhibiting ALKBH5, which in turn enhanced YTHDF1-dependent TRAF4 translation and suppressed adipogenesis