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H 2 O 2 produced during the oxidative folding of endoplasmic reticulum proteins has been found to regulate the signal transduction process of nuclear factor E2-related factor 2 (Nrf2), which in turn regulates the expression of downstream glutathione peroxidase 8 (GPX8), which in turn can participate in ER calcium regulation through endoplasmic reticulum calcium ATPase (SERCA) (Figure 7)
Glutathione metabolism in brain: metabolic interaction between astrocytes and neurons in the defense against oxidative stress
84%) [Figure 13.30]
A solution of 5-aminopentyltriphenylphosphonium bromide hydrogenbromide 58 (368 mg, 724 mol) in anhydrous dichloromethane (2.0 mL) was then added dropwise to the solution and the mixture allowed to warm to RT over 3 h
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