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The addition of GIP receptor activation appears to amplify the metabolic and weight loss effects beyond what GLP-1 alone can achieve

Clinical Practice Guideline for the Treatment of Obstructive Sleep Apnea and Snoring with Oral Appliance Therapy: An Update for 2015

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Richie JP Jr, Nichenametla S, Neiber W, et al

"Weight loss and changes in nutritional status, common consequences of GLP-1 receptor agonist therapy, are established risk factors for telogen effluvium, a common and typically transient form of non-scarring hair loss, providing a plausible biological mechanism for this association," write the researchers