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Research literature suggests that this axis is not governed by linear onoff signaling, but rather by pulsatile, context-sensitive interactions shaped by feedback loops and receptor specificity

Mitani M, Kaji H, et al

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However, there is research suggesting that combined contraceptives (like the pill) can become less effective if used at the same time as an anti-fungal medication called griseofulvin [4]

Many men with digestive issues, low stomach acid, or genetic absorption problems may see less benefit from pills