On top of that, treatment with SB also reduces the expression of PCNA, cyclin E, and cdc2 in hCG-treated leiomyoma cells (Lee et al., 2004c)
Int J Mol Sci (2021) 22(3):1273
This is where therapeutic effects typically begin
Whether they ever will depends less on the receptor, whose biology is no longer in serious doubt, than on two engineering problems that the recent failures have brought into focus: getting the compound to the right neurons, and getting the right patients into the trial
This, along with more strict requirements for indication of need for PPIs, as suggested by the AGA, and periodic reevaluations of efficacy could possibly aid in prevention of PPI associated side effects
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