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In vitro studies showed liraglutide reversed TGF-1 (5 ng/ml) combining IL-1 (5 ng/ml) induced endothelial-mesenchymal transition (EndMT) in human umbilical vein endothelial cells (HUVECs), which could be abolished by GLP-1 receptor antagonist (exendin-3)
Mechanical signals from each strip were amplified with an amplifier, recorded, and analyzed using Med Lab 6.0 software (MedEase, Nanjing, China)
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Overall, a substantial proportion of the retatrutide group (64-100%) were able to achieve a significant weight loss of 5% or more, compared to just 27% in the placebo group
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