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In NDI1-expressing adipocyte- Bmal1 KO mice, we also observed reduced hepatic steatosis, smaller white adipocyte size and restored ratios of NAD + -to-NADH and ATP-to-ADP (Extended Data Fig
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It is essential for: Mitochondrial energy production (ATP) DNA repair and cellular resilience Activation of sirtuins , proteins involved in metabolism and healthy aging Redox balance , helping cells respond to metabolic stress NAD levels naturally decline with age and may be lower in people with metabolic disease, chronic inflammation, or prolonged stress
