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PubMed laboratory research record [PMID: 42072144] PubMed record related to this compound for laboratory literature review
Serious adverse effects, though rare, include pancreatitis, gallbladder disease, acute kidney injury (typically secondary to dehydration from gastrointestinal symptoms), and hypoglycemia when combined with insulin or sulfonylureas
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As one obesity medicine specialist explained, "the increased risk of thyroid cancers is specifically in those with a personal or family history of multiple endocrine neoplasia 2 (MEN2) syndrome or medullary thyroid carcinoma [MTC]." Reassuringly, randomized trials failed to detect any increase in calcitonin levels and did not confirm the risk of pancreatitis, whereas a significant increase in cholelithiasis was highlighted
A model of the backbone of Ex4-d-Ala from the cryo-EM maps of GLP-1R conformer 2 is shown in transparent purple for reference