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Who Should Take It
Summary: Combination therapy with GLP-1 receptor agonists and SGLT2 inhibitors uses two distinct drug classes simultaneously to improve glycaemic control in type 2 diabetes through complementary mechanisms whilst providing cardiovascular and renal protection
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Fortunately, a meta-analysis of SGLT2i CVOTs found that diabetic ketoacidosis was rare, occurring in 0.1 to 2.2 per 1,000 person-years in those treated with a SGLT2i, albeit with a significantly greater risk compared to placebo (HR, 2.46
GLP-1 receptor agonists (also known as glucagon-like peptide-1 agonists) are a popular class of medications used in conjunction with a reduced-calorie diet and exercise to help manage Type 2 diabetes and support weight loss in individuals with obesity
For understanding side effects, see GLP-1 side effects
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