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Who Should Avoid It : See shared GLP-1 CI/precautions above

Some studies suggest combining GLP-1 therapy with metformin may provide additive benefits

This should include: HbA1c measurement to objectively assess glycaemic control Review of home blood glucose monitoring data (if applicable) Assessment for diabetes complications (retinopathy, nephropathy, neuropathy) Evaluation of cardiovascular risk factors Screening for other conditions affecting glucose control (such as thyroid dysfunction) if clinically indicated Consider medication intensification

A 5mg vial with 2ml water yields 2.5mg/ml concentration

Timing Day before shot: Protein, gentle carbs, hydration

This results in prolonged intervals between meals, decreased calorie intake, and delayed gastric emptying, ultimately contributing to significant weight loss one of the drugs most prominent side effects