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Functionalized siRNA-chitosan nanoformulations promote triple-negative breast cancer cell death via blocking the miRNA-21/AKT/ERK signaling axis: in-silico and in vitro studies

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Researchers examine how KPV blocks the nuclear translocation of Nuclear Factor kappa B (NF-$\kappa$B) in both intestinal epithelial cells and active immune cells, subsequently shutting down the transcription and downstream secretion of damaging pro-inflammatory cytokines such as TNF-$\alpha$, IL-1$\beta$, and IL-6

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