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Activation of sirtuins: Particularly SIRT1 and SIRT3, which are NAD+-dependent deacetylases involved in metabolic regulation and stress resistance 42

The mean oral cavity pH over the course of 48 hours is approximately 7.27

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The presence of targeting ligands resulted in two-fold higher uptake of nanocarriers in the control healthy (2.09 ng/g protein) and PD organoids (1.85 ng/g protein) compared to uptake of the non-targeted nanocarriers in the control (1.01 ng/g protein) and PD (0.92 ng/g protein) organoids (Fig