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Enzymatic antioxidant defense cannot rely solely on SOD, because that would result in markedly increased tissue damage due to high accumulated levels of intracellular H 2 O 2 , the substrate for production of OH via the Fenton reaction
Granulomatous inflammation with characteristic focal or multifocal nodular collections of mononuclear epitheloid cells and occasional giant cells associated with areas of hepatocyte necrosis can be considered a specific subtype of mononuclear cells infiltration and part of the spectrum comprising chronic inflammation of the liver (Figures 7477)
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