& Huc, L
Coupling of cobaltcarbon bond homolysis and hydrogen atom abstraction in adenosylcobalamin-dependent glutamate mutase
The researchers assessed the molecular mechanism of action of Nrf2 by Western blot, luciferase reporter gene assay, and qRT-PCR analysis, and detected the changes of intracellular ROS, and lipids by fluorescence assay
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Bubeck Wardenburg, J
and actually SARS-CoV-2 causing COVID-19, all are characterized by persistent inflammation, continuous production of reactive oxygen/nitrogen species and oxidative stress that predominate over the antioxidant defenses (GSH and free radical scavenger enzymes) resulting in cell/tissue/organ aging associated with early (premature) chronic inflammation/inflammaging. We propose that, although inflammaging was introduced for the aging process (276289), it could also apply to early (premature) tissue and organ aging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses, especially low GSH levels, in younger individuals
