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Its best-characterized local mechanism is upregulation of vascular endothelial growth factor (VEGF) and related angiogenic signaling, which promotes the formation of new blood vessels in damaged mucosal tissue

cell cycle G 1 /S checkpoint: RB [S612], RB1 [S780]

Furthermore, the dopamine metabolism process inherent to vulnerable nigrostriatal neurons intrinsically generates ROS, further damaging mitochondrial complex I and proteasome function, creating a vicious cycle of oxidative stress and neurodegeneration [336]

This usually goes away in a day or two

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