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Importantly, the authors demonstrated that the peptides which were most able to produce weight loss without hyperglycaemia demonstrated balanced potency at the GLP-1 and glucagon receptors

And honestly

Missing a single criterion is the most common reason requests are denied

Other GLP-1 drugs are made up of larger molecules that are not easily absorbed in the gastrointestinal tract

The drug itself interacts with the part of the brain that controls the appetite, preventing people from overeating