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The PI3K/AKT/mTOR pathway was recently showed to reduce oxidative stress and promote cell survival of breast epithelial cells segregated from the ECM by strengthening flux through the oxidative PPP (195) PIK3CA mutation, which leads to increased PI3K activity, is the most common somatic mutation in breast cancer, and 36% of patients with HR+/HER2- breast cancer are PIK3CA mutated (196)

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And then maybe and I say this again, we have this conversation a lot in our students