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Phospholipid peroxidation can be catalyzed by oxidoreductases, including POR and NADH-cytochrome b5 reductase (CYB5R1), which can generate hydrogen peroxide (H 2 O 2 ) through transferring electron and hydrogen atoms from NAD(P)H to oxygen, following which H 2 O 2 produces reactive hydroxyl radicals through Fenton reaction for the peroxidation of membrane PL-PUFA chains, thus vandalizing the integrity of the cellular membrane and initiating ferroptosis [14]

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